| Reaction Details |
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 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase |
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| Ligand | BDBM50340952 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_739836 (CHEMBL1762896) |
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| IC50 | 1700±n/a nM |
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| Citation |  Crew, AP; Bhagwat, SV; Dong, H; Bittner, MA; Chan, A; Chen, X; Coate, H; Cooke, A; Gokhale, PC; Honda, A; Jin, M; Kahler, J; Mantis, C; Mulvihill, MJ; Tavares-Greco, PA; Volk, B; Wang, J; Werner, DS; Arnold, LD; Pachter, JA; Wild, R; Gibson, NW Imidazo[1,5-a]pyrazines: orally efficacious inhibitors of mTORC1 and mTORC2. Bioorg Med Chem Lett21:2092-7 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RAF proto-oncogene serine/threonine-protein kinase |
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| Name: | RAF proto-oncogene serine/threonine-protein kinase |
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| Synonyms: | C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene
serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase
RAF | Serine/threonine-protein kinase C-Raf | cRaf |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 73082.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04049 |
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| Residue: | 648 |
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| Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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| BDBM50340952 |
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| n/a |
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| Name | BDBM50340952 |
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| Synonyms: | 4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-3-yl)-N,N-dimethylpiperidine-1-carboxamide | CHEMBL1762114 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25N7O |
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| Mol. Mass. | 403.4802 |
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| SMILES | CN(C)C(=O)N1CCC(CC1)c1nc(-c2cc3ccccc3[nH]2)c2c(N)nccn12 |
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| Structure | 
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