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TargetCannabinoid receptor 1
LigandBDBM50341130
Substrate/Competitorn/a
Meas. Tech.ChEMBL_740279 (CHEMBL1764225)
IC50 41±n/a nM
Citation Kitajima, MIwai, MKikura-Hanajiri, RGoda, YIida, MYabushita, HTakayama, H Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity. Bioorg Med Chem Lett21:1962-4 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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BDBM50341130
n/a
NameBDBM50341130
Synonyms:CHEMBL445022 | voacamine
TypeSmall organic molecule
Emp. Form.C44H56N4O5
Mol. Mass.720.9392
SMILESCC[C@H]1C[C@@H]2CN3CCC4C(Nc5cc([C@H]6C[C@H]7C(C\C7=C\C)[C@@H](C(Cc7c6[nH]c6ccccc76)NC)C(=O)OC)c(OC)cc45)[C@](C2)([C@H]13)C(=O)OC |r,TLB:1:2:47.46:6.5,49:46:2.3:6.5,THB:7:6:2.3:47.46,10:46:2.3:6.5|
Structure
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