| Reaction Details |
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 | Report a problem with these data |
| Target | Glucose-dependent insulinotropic receptor |
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| Ligand | BDBM50341309 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_742672 (CHEMBL1769550) |
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| Ki | 140±n/a nM |
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| Citation |  McClure, KF; Darout, E; Guimarães, CR; DeNinno, MP; Mascitti, V; Munchhof, MJ; Robinson, RP; Kohrt, J; Harris, AR; Moore, DE; Li, B; Samp, L; Lefker, BA; Futatsugi, K; Kung, D; Bonin, PD; Cornelius, P; Wang, R; Salter, E; Hornby, S; Kalgutkar, AS; Chen, Y Activation of the G-protein-coupled receptor 119: a conformation-based hypothesis for understanding agonist response. J Med Chem54:1948-52 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucose-dependent insulinotropic receptor |
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| Name: | Glucose-dependent insulinotropic receptor |
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| Synonyms: | GP119_RAT | Gpr119 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51687.59 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1506411 |
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| Residue: | 468 |
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| Sequence: | MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISG
LVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGL
VAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLL
FVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSP
FLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLCHMALGLLAD
GSTQPQIETLKGKEERKKVGRKTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDACDTQTLY
TCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDTQTLYTCDAQTLYTCDA
QTLYTCDAQTLYTCDAQTLYTSSLVTGQTEQTPLKRANMSDPLRTCRG
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|
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| BDBM50341309 |
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| n/a |
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| Name | BDBM50341309 |
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| Synonyms: | CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)piperidine-1-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26N4O4 |
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| Mol. Mass. | 386.4448 |
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| SMILES | CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cccnc2C)c1C |
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| Structure | 
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