| Reaction Details |
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 | Report a problem with these data |
| Target | Ceramide kinase |
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| Ligand | BDBM50341519 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_742032 (CHEMBL1768895) |
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| Ki | >1000±n/a nM |
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| Citation |  Charrier, JD; Miller, A; Kay, DP; Brenchley, G; Twin, HC; Collier, PN; Ramaya, S; Keily, SB; Durrant, SJ; Knegtel, RM; Tanner, AJ; Brown, K; Curnock, AP; Jimenez, JM Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors. J Med Chem54:2341-50 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ceramide kinase |
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| Name: | Ceramide kinase |
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| Synonyms: | Acylsphingosine kinase | CERK | CERK1_HUMAN | KIAA1646 | LK4 | Lipid kinase 4 | hCERK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59996.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_742032 |
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| Residue: | 537 |
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| Sequence: | MGATGAAEPLQSVLWVKQQRCAVSLEPARALLRWWRSPGPGAGAPGADACSVPVSEIIAV
EETDVHGKHQGSGKWQKMEKPYAFTVHCVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLR
EMLEKLTSRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETL
YEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGS
TDCVCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDS
EKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVCRQSKQQ
LEEEQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDL
ILIRKCSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKHMEDEDSDLKEGGKKRF
GHICSSHPSCCCTVSNSSWNCDGEVLHSPAIEVRVHCQLVRLFARGIEENPKPDSHS
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| BDBM50341519 |
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| n/a |
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| Name | BDBM50341519 |
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| Synonyms: | (S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)benzoylamino)-5-(6-(methylamino)pyrazin-2-yl)-(1H)-pyridin-2-one | CHEMBL1765781 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H31N7O2 |
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| Mol. Mass. | 473.57 |
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| SMILES | CNc1cncc(n1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1 |r| |
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| Structure | 
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