Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetDiacylglycerol O-acyltransferase 1
LigandBDBM50341773
Substrate/Competitorn/a
Meas. Tech.ChEMBL_743546 (CHEMBL1767987)
IC50 128±n/a nM
Citation Qian, YWertheimer, SJAhmad, MCheung, AWFirooznia, FHamilton, MMHayden, SLi, SMarcopulos, NMcDermott, LTan, JYun, WGuo, LPamidimukkala, AChen, YHuang, KSRamsey, GBWhittard, TConde-Knape, KTaub, RRondinone, CMTilley, JBolin, D Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes. J Med Chem54:2433-46 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 1
Name:Diacylglycerol O-acyltransferase 1
Synonyms:ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:Protein
Mol. Mass.:55297.82
Organism:Homo sapiens (Human)
Description:O75907
Residue:488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50341773
n/a
NameBDBM50341773
Synonyms:2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid(1'-Cyclopropanecarbonyl-1',2',3',4',5',6'-hexahydro[2,4']bipyridinyl-5-yl)amide | CHEMBL1766890
TypeSmall organic molecule
Emp. Form.C25H23F3N4O3
Mol. Mass.484.4703
SMILESFC(F)(F)c1oc(nc1C(=O)Nc1ccc(nc1)C1CCN(CC1)C(=O)C1CC1)-c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: