| Reaction Details |
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 | Report a problem with these data |
| Target | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
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| Ligand | BDBM50341812 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_743598 (CHEMBL1768098) |
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| IC50 | 8.4±n/a nM |
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| Citation |  Shiozaki, M; Maeda, K; Miura, T; Kotoku, M; Yamasaki, T; Matsuda, I; Aoki, K; Yasue, K; Imai, H; Ubukata, M; Suma, A; Yokota, M; Hotta, T; Tanaka, M; Hase, Y; Haas, J; Fryer, AM; Laird, ER; Littmann, NM; Andrews, SW; Josey, JA; Mimura, T; Shinozaki, Y; Yoshiuchi, H; Inaba, T Discovery of (1S,2R,3R)-2,3-dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: novel and highly selective aggrecanase inhibitors. J Med Chem54:2839-63 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| A disintegrin and metalloproteinase with thrombospondin motifs 5 |
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| Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
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| Synonyms: | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) | ADAMTS11 | ADAMTS5 | ADMP2 | ATS5_HUMAN | Aggrecanase-2 | Metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) |
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| Type: | Enzyme |
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| Mol. Mass.: | 101769.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UNA0 |
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| Residue: | 930 |
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| Sequence: | MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGH
PHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGT
SAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGR
VYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLD
QSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANR
LYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD
AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH
DDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
LGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGT
PCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPR
NNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVL
PADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDK
CGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKK
NGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPT
KPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTV
QCQDGNRKLAKGCPLSQRPSAFKQCLLKKC
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| BDBM50341812 |
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| n/a |
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| Name | BDBM50341812 |
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| Synonyms: | (1S,2R,3R)-2.3-Dimethyl-1-(8-fluoro-1,2,3,4-tetrahydropyrido[3',4':4,5]imidazo[1,2-a]pyridine-2-sulfonylamino)-2-phenylcyclopropanecarboxylic Acid | CHEMBL1767014 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23FN4O4S |
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| Mol. Mass. | 458.506 |
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| SMILES | C[C@@H]1[C@](C)(c2ccccc2)[C@]1(NS(=O)(=O)N1CCc2c(C1)nc1cc(F)ccn21)C(O)=O |r| |
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| Structure | 
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