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TargetPoly [ADP-ribose] polymerase 2
LigandBDBM50341862
Substrate/Competitorn/a
Meas. Tech.ChEMBL_743712 (CHEMBL1767526)
IC50 6500±n/a nM
Citation Sunderland, PTWoon, ECDhami, ABergin, ABMahon, MFWood, PJJones, LATully, SRLloyd, MDThompson, ASJavaid, HMartin, NMThreadgill, MD 5-Benzamidoisoquinolin-1-ones and 5-(κ-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2). J Med Chem54:2049-59 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Poly [ADP-ribose] polymerase 2
Name:Poly [ADP-ribose] polymerase 2
Synonyms:2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 2 | ADPRT-2 | ARTD2 | Adprt2 | Adprtl2 | Aspartl2 | DNA ADP-ribosyltransferase PARP2 | NAD(+) ADP-ribosyltransferase 2 | PARP-2 | PARP2_MOUSE | Parp2 | Poly (ADP-ribose) Polymerase-2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (Parp2) | Poly [ADP-ribose] polymerase-2 | Poly[ADP-ribose] synthase 2 | Poly[ADP-ribose] synthetase 2 | Protein poly-ADP-ribosyltransferase PARP2 | mPARP-2 | pADPRT-2 | poly-ADP-ribose polymerase 2 (PARP2)
Type:n/a
Mol. Mass.:63409.97
Organism:Mus musculus (Mouse)
Description:Alexis Biochemicals, Cat. no. ALX-201-064-C020
Residue:559
Sequence:
MAPRRQRSGSGRRVLNEAKKVDNGNKATEDDSPPGKKMRTCQRKGPMAGGKDADRTKDNR
DSVKTLLLKGKAPVDPECAAKLGKAHVYCEGDDVYDVMLNQTNLQFNNNKYYLIQLLEDD
AQRNFSVWMRWGRVGKTGQHSLVTCSGDLNKAKEIFQKKFLDKTKNNWEDRENFEKVPGK
YDMLQMDYAASTQDESKTKEEETLKPESQLDLRVQELLKLICNVQTMEEMMIEMKYDTKR
APLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALVEACNEFYTRIPHDFGLSIPPVIRTE
KELSDKVKLLEALGDIEIALKLVKSERQGLEHPLDQHYRNLHCALRPLDHESNEFKVISQ
YLQSTHAPTHKDYTMTLLDVFEVEKEGEKEAFREDLPNRMLLWHGSRLSNWVGILSHGLR
VAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPK
AQGLLRGKHSTKGMGKMAPSPAHFITLNGSTVPLGPASDTGILNPEGYTLNYNEFIVYSP
NQVRMRYLLKIQFNFLQLW
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BDBM50341862
n/a
NameBDBM50341862
Synonyms:5-(4-Methylbenzamido)isoquinolin-1-one | CHEMBL1767049
TypeSmall organic molecule
Emp. Form.C17H14N2O2
Mol. Mass.278.3053
SMILESCc1ccc(cc1)C(=O)Nc1cccc2c1cc[nH]c2=O
Structure
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