| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Farnesyl diphosphate synthase |
|---|
| Ligand | BDBM12576 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_743414 (CHEMBL1767768) |
|---|
| IC50 | 74±n/a nM |
|---|
| Citation |  Rosso, VS; Szajnman, SH; Malayil, L; Galizzi, M; Moreno, SN; Docampo, R; Rodriguez, JB Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. Bioorg Med Chem19:2211-7 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Farnesyl diphosphate synthase |
|---|
| Name: | Farnesyl diphosphate synthase |
|---|
| Synonyms: | n/a |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 69493.18 |
|---|
| Organism: | Toxoplasma gondii |
|---|
| Description: | ChEMBL_1282507 |
|---|
| Residue: | 646 |
|---|
| Sequence: | MVDAVSLVSCRARHSHSLFAFSLSRRSCIQKHRFFSYVKSVPSSLPSPSSSSSPFTLSPR
RRCLPPLVLPLEAAGHLPPALHSGSGISCPRSSSLSLSSSSPMRAPPSISLGLPPAQRPS
LCFSPTSRLSAPVSPWSFSRQLSLATLAPLASVSSWKKAAALPKPDGAAAVSDERTSAER
ADALAGAWRASASHVEDRFKQAFPEVRGTLLSHIAGLDLPASLSARLLSYYARLLDYTCS
GGKLTRGILVLYAAAAASHAPVLPPPSPSPAAAPASSASSVSSSPCSSSLAESERVPGSA
LSPALPPSSFRCLAALGWCVELLQSCFLVMDDVMDHSLTRRGKQCWYRCDGIGVSNAVND
SLVLEAAVYRVLREYLGDHPAYVQLQDLLLGNTFTTLIGQHLDSEDALAALSEASQNLES
RQSEDNSSASSATAAGSSLLRDASLSDKDFTHHSYVSSSLSSSRSSPSLSASSLPSSEVL
AQKLADRQATVARLKTSHYSFYLPTALGMTYGGLTDPALMAQAKELCLAIGEYFQVQDDY
LDCFSDPKISGKIGSDIQEKKCCWLFVQAVRRASREDLAQLLRVYGQPEYVDWVKDLYRR
LDLTSLYFQYEEETLAKLRRSVSSFPHDGMKAFFGLVLGRLHKRQK
|
|
|
|---|
| BDBM12576 |
|---|
| n/a |
|---|
| Name | BDBM12576 |
|---|
| Synonyms: | Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound 64 | RIS | Risdronate | US11279719, Example Risedronic acid RIS | [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C7H11NO7P2 |
|---|
| Mol. Mass. | 283.1123 |
|---|
| SMILES | OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
