| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 26A1 |
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| Ligand | BDBM50342132 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_744044 (CHEMBL1768149) |
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| IC50 | 100±n/a nM |
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| Citation |  Gomaa, MS; Bridgens, CE; Aboraia, AS; Veal, GJ; Redfern, CP; Brancale, A; Armstrong, JL; Simons, C Small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26): synthesis and biological evaluation of imidazole methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates. J Med Chem54:2778-91 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 26A1 |
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| Name: | Cytochrome P450 26A1 |
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| Synonyms: | CP26A_HUMAN | CYP26 | CYP26A1 | Cytochrome CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | P450RAI1 | Retinoic acid 4-hydroxylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 56216.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43174 |
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| Residue: | 497 |
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| Sequence: | MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM
VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL
GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE
VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR
NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG
GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI
KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM
LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV
YPVDNLPARFTHFHGEI
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| BDBM50342132 |
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| n/a |
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| Name | BDBM50342132 |
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| Synonyms: | 3-[4-(Benzothiazol-2-ylamino)-phenyl]-3-imidazol-1-yl-2,2-dimethylpropionicAcidMethyl Ester | CHEMBL1766009 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22N4O2S |
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| Mol. Mass. | 406.501 |
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| SMILES | COC(=O)C(C)(C)C(c1ccc(Nc2nc3ccccc3s2)cc1)n1ccnc1 |
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| Structure | 
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