Reaction Details |
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Target | Cytochrome P450 26A1 |
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Ligand | BDBM50342138 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_744044 (CHEMBL1768149) |
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IC50 | >1000±n/a nM |
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Citation | Gomaa, MS; Bridgens, CE; Aboraia, AS; Veal, GJ; Redfern, CP; Brancale, A; Armstrong, JL; Simons, C Small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26): synthesis and biological evaluation of imidazole methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates. J Med Chem54:2778-91 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 26A1 |
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Name: | Cytochrome P450 26A1 |
Synonyms: | CP26A_HUMAN | CYP26 | CYP26A1 | Cytochrome CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | P450RAI1 | Retinoic acid 4-hydroxylase |
Type: | Enzyme |
Mol. Mass.: | 56216.16 |
Organism: | Homo sapiens (Human) |
Description: | O43174 |
Residue: | 497 |
Sequence: | MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM
VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL
GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE
VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR
NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG
GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI
KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM
LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV
YPVDNLPARFTHFHGEI
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BDBM50342138 |
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n/a |
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Name | BDBM50342138 |
Synonyms: | CHEMBL1766014 | Methyl 3-(1H-Imidazol-1-yl)-2,3-dimethyl-3-((4-naphthalene-2-yloxy)phenyl)propanoate |
Type | Small organic molecule |
Emp. Form. | C25H24N2O3 |
Mol. Mass. | 400.4697 |
SMILES | COC(=O)C(C)(C)C(c1ccc(Oc2ccc3ccccc3c2)cc1)n1ccnc1 |
Structure |
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