Ki Summary

Reaction Details

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Target

Steroid 17-alpha-hydroxylase/17,20 lyase

Ligand

BDBM50342190

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_742803 (CHEMBL1769806)

IC50

19±n/a nM

Citation

Kaku, T; Tsujimoto, S; Matsunaga, N; Tanaka, T; Hara, T; Yamaoka, M; Kusaka, M; Tasaka, A 17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors. Bioorg Med Chem19:2428-42 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Steroid 17-alpha-hydroxylase/17,20 lyase

Name:

Steroid 17-alpha-hydroxylase/17,20 lyase

Synonyms:

Type:

Enzyme

Mol. Mass.:

57255.68

Organism:

Rattus norvegicus (Rat)

Description:

P11715

Residue:

507

Sequence:

MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNFFKLQEKY
GPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSS
WHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVTNIICA
ICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPNKGLEVIKGYAKVRNE
VLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFG
AGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLMLEATIREVL
RIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPT
GSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPK
VVFLIDPFKVKITVRQAWMDAQAEVST

BDBM50342190

n/a

Name

BDBM50342190

Synonyms:

(S)-N-(4'-(1-hydroxy-1-(1H-imidazol-4-yl)propyl)biphenyl-3-yl)acetamide | CHEMBL1766191

Type

Small organic molecule

Emp. Form.

C20H21N3O2

Mol. Mass.

335.3996

SMILES

CC[C@@](O)(c1cnc[nH]1)c1ccc(cc1)-c1cccc(NC(C)=O)c1 |r|

Structure