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TargetSolute carrier family 22 member 12
LigandBDBM50158460
Substrate/Competitorn/a
Meas. Tech.ChEMBL_743865 (CHEMBL1767808)
IC50 26±n/a nM
Citation Wempe, MFJutabha, PQuade, BIwen, TJFrick, MMRoss, IRRice, PJAnzai, NEndou, H Developing potent human uric acid transporter 1 (hURAT1) inhibitors. J Med Chem54:2701-13 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Solute carrier family 22 member 12
Name:Solute carrier family 22 member 12
Synonyms:OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:Enzyme
Mol. Mass.:59638.65
Organism:Homo sapiens (Human)
Description:Q96S37
Residue:553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
GTLGNSVLKSTQF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50158460
n/a
NameBDBM50158460
Synonyms:(3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone | 2-ethyl-3-(3,5-dibrom-4-hydroxybenzoyl)benzofuran | 3,5-dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone | Benzbromarone | CHEMBL388590 | US9725430, Compound 1 | US9856239, benzbromarone | US9962362, Compound 1 | Uroleap (TN) | cid_2333
TypeSmall organic molecule
Emp. Form.C17H12Br2O3
Mol. Mass.424.083
SMILESCCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1
Structure
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