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TargetHydroxycarboxylic acid receptor 2
LigandBDBM50342424
Substrate/Competitorn/a
Meas. Tech.ChEMBL_744532 (CHEMBL1772553)
Ki 4200±n/a nM
Citation van Veldhoven, JPBlad, CCArtsen, CMKlopman, CWolfram, DRAbdelkadir, MJLane, JRBrussee, JIjzerman, AP Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A). Bioorg Med Chem Lett21:2736-9 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hydroxycarboxylic acid receptor 2
Name:Hydroxycarboxylic acid receptor 2
Synonyms:G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41868.22
Organism:Homo sapiens (Human)
Description:Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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BDBM50342424
n/a
NameBDBM50342424
Synonyms:CHEMBL1771639 | Isopropyl fumarate
TypeSmall organic molecule
Emp. Form.C7H10O4
Mol. Mass.158.1519
SMILESCC(C)OC(=O)\C=C\C(O)=O
Structure
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