Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHydroxycarboxylic acid receptor 2
LigandBDBM50342533
Substrate/Competitorn/a
Meas. Tech.ChEMBL_744661 (CHEMBL1772682)
IC50 13±n/a nM
Citation Imbriglio, JEDiRocco, DBodner, RRaghavan, SChen, WMarley, DEsser, CHolt, TGWolff, MSTaggart, AKWaters, MGTata, JRColletti, SL The discovery of high affinity agonists of GPR109a with reduced serum shift and improved ADME properties. Bioorg Med Chem Lett21:2721-4 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hydroxycarboxylic acid receptor 2
Name:Hydroxycarboxylic acid receptor 2
Synonyms:G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41868.22
Organism:Homo sapiens (Human)
Description:Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50342533
n/a
NameBDBM50342533
Synonyms:2-(3-(7-hydroxy-4,5-dihydropyrazolo[1,5-a]quinolin-2-yl)propanamido)benzoic acid | CHEMBL1770173
TypeSmall organic molecule
Emp. Form.C21H19N3O4
Mol. Mass.377.3933
SMILESOC(=O)c1ccccc1NC(=O)CCc1cc2CCc3cc(O)ccc3-n2n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: