Reaction Details |
| Report a problem with these data |
Target | Hydroxycarboxylic acid receptor 2 |
---|
Ligand | BDBM50342536 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_744661 (CHEMBL1772682) |
---|
IC50 | 41±n/a nM |
---|
Citation | Imbriglio, JE; DiRocco, D; Bodner, R; Raghavan, S; Chen, W; Marley, D; Esser, C; Holt, TG; Wolff, MS; Taggart, AK; Waters, MG; Tata, JR; Colletti, SL The discovery of high affinity agonists of GPR109a with reduced serum shift and improved ADME properties. Bioorg Med Chem Lett21:2721-4 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Hydroxycarboxylic acid receptor 2 |
---|
Name: | Hydroxycarboxylic acid receptor 2 |
Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 41868.22 |
Organism: | Homo sapiens (Human) |
Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
Residue: | 363 |
Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
|
|
|
BDBM50342536 |
---|
n/a |
---|
Name | BDBM50342536 |
Synonyms: | (R)-2-(2-amino-3-(3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl)propanamido)benzoic acid | CHEMBL1770176 |
Type | Small organic molecule |
Emp. Form. | C18H16N4O5 |
Mol. Mass. | 368.3434 |
SMILES | N[C@H](Cc1nc(no1)-c1ccc(O)cc1)C(=O)Nc1ccccc1C(O)=O |r| |
Structure |
|