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TargetMuscarinic acetylcholine receptor M3
LigandBDBM50342538
Substrate/Competitorn/a
Meas. Tech.ChEMBL_744881 (CHEMBL1772902)
IC50 300±n/a nM
Citation Andrews, MDFish, PVBlagg, JBrabham, TKBrennan, PEBridgeland, ABrown, ADBungay, PJConlon, KMEdmunds, NJaf Forselles, KGibbons, CPGreen, MPHanton, GHolbrook, MJessiman, ASMcIntosh, KMcMurray, GNichols, CLRoot, JAStorer, RISutton, MRWard, RVWestbrook, DWhitlock, GA Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence. Bioorg Med Chem Lett21:2715-20 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M3
Name:Muscarinic acetylcholine receptor M3
Synonyms:ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:Enzyme
Mol. Mass.:66151.03
Organism:Homo sapiens (Human)
Description:P20309
Residue:590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
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  Blast E-value cutoff:
BDBM50342538
n/a
NameBDBM50342538
Synonyms:2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepine | CHEMBL1770373
TypeSmall organic molecule
Emp. Form.C15H17N3
Mol. Mass.239.3156
SMILESC(c1ccccc1)c1ncc2CCNCCc2n1
Structure
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