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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neuropeptide Y receptor type 1 | ||
| Ligand | BDBM50342722 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_744205 (CHEMBL1771962) | ||
| Ki | 383±n/a nM | ||
| Citation |  Griffith, DA; Hargrove, DM; Maurer, TS; Blum, CA; De Lombaert, S; Inthavongsay, JK; Klade, LE; Mack, CM; Rose, CR; Sanders, MJ; Carpino, PA Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists. Bioorg Med Chem Lett21:2641-5 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neuropeptide Y receptor type 1 | |||
| Name: | Neuropeptide Y receptor type 1 | ||
| Synonyms: | NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 44399.07 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | NPY-Y1 NPY1R HUMAN::P25929 | ||
| Residue: | 384 | ||
| Sequence: |
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| BDBM50342722 | |||
| n/a | |||
| Name | BDBM50342722 | ||
| Synonyms: | CHEMBL1771266 | N1-(3-(2,6-dichloro-4-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl)-N2-(2,2-difluoroethyl)ethane-1,2-diamine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H21Cl2F2N5O | ||
| Mol. Mass. | 444.306 | ||
| SMILES | COc1cc(Cl)c(-c2c(C)nn3c(NCCNCC(F)F)cc(C)nc23)c(Cl)c1 |(41.2,-48.94,;42.74,-48.92,;43.49,-47.58,;42.71,-46.25,;43.46,-44.91,;42.69,-43.58,;45,-44.9,;45.76,-43.56,;44.85,-42.31,;43.31,-42.31,;45.76,-41.06,;47.23,-41.54,;48.56,-40.77,;48.56,-39.23,;49.89,-38.46,;51.22,-39.22,;52.56,-38.45,;53.88,-39.23,;55.22,-38.47,;55.23,-36.93,;56.55,-39.24,;49.9,-41.53,;49.9,-43.08,;51.24,-43.85,;48.56,-43.86,;47.23,-43.09,;45.79,-46.21,;47.33,-46.19,;45.04,-47.56,)| | ||
| Structure | 
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