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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neuropeptide Y receptor type 1 | ||
| Ligand | BDBM50342728 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_744205 (CHEMBL1771962) | ||
| Ki | 3±n/a nM | ||
| Citation |  Griffith, DA; Hargrove, DM; Maurer, TS; Blum, CA; De Lombaert, S; Inthavongsay, JK; Klade, LE; Mack, CM; Rose, CR; Sanders, MJ; Carpino, PA Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists. Bioorg Med Chem Lett21:2641-5 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neuropeptide Y receptor type 1 | |||
| Name: | Neuropeptide Y receptor type 1 | ||
| Synonyms: | NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 44399.07 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | NPY-Y1 NPY1R HUMAN::P25929 | ||
| Residue: | 384 | ||
| Sequence: |
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| BDBM50342728 | |||
| n/a | |||
| Name | BDBM50342728 | ||
| Synonyms: | CHEMBL1771260 | N1-(3-(2,6-dichloro-4-ethoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl)-N2-(tetrahydro-2H-pyran-4-yl)ethane-1,2-diamine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H29Cl2N5O2 | ||
| Mol. Mass. | 478.415 | ||
| SMILES | CCOc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 |(-10.58,-34.36,;-9.79,-35.68,;-8.25,-35.66,;-7.5,-34.32,;-8.28,-32.99,;-7.53,-31.65,;-8.3,-30.33,;-5.99,-31.65,;-5.23,-30.31,;-6.14,-29.05,;-7.68,-29.05,;-5.23,-27.8,;-3.76,-28.28,;-2.43,-27.52,;-2.43,-25.98,;-1.1,-25.2,;.23,-25.97,;1.57,-25.2,;2.89,-25.98,;2.88,-27.52,;4.2,-28.3,;5.54,-27.54,;5.56,-26,;4.23,-25.21,;-1.1,-28.28,;-1.09,-29.83,;.25,-30.6,;-2.43,-30.6,;-3.76,-29.83,;-5.2,-32.96,;-3.66,-32.94,;-5.95,-34.3,)| | ||
| Structure | 
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