Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neuropeptide Y receptor type 1 | ||
| Ligand | BDBM50342721 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_744205 (CHEMBL1771962) | ||
| Ki | 1±n/a nM | ||
| Citation |  Griffith, DA; Hargrove, DM; Maurer, TS; Blum, CA; De Lombaert, S; Inthavongsay, JK; Klade, LE; Mack, CM; Rose, CR; Sanders, MJ; Carpino, PA Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists. Bioorg Med Chem Lett21:2641-5 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neuropeptide Y receptor type 1 | |||
| Name: | Neuropeptide Y receptor type 1 | ||
| Synonyms: | NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 44399.07 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | NPY-Y1 NPY1R HUMAN::P25929 | ||
| Residue: | 384 | ||
| Sequence: |
| ||
| BDBM50342721 | |||
| n/a | |||
| Name | BDBM50342721 | ||
| Synonyms: | CHEMBL1771259 | N1-(3-(2,6-dichloro-4-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl)-N2-(tetrahydro-2H-pyran-4-yl)ethane-1,2-diamine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H27Cl2N5O2 | ||
| Mol. Mass. | 464.388 | ||
| SMILES | COc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 |(28.08,-21.34,;29.62,-21.32,;30.38,-19.98,;29.6,-18.65,;30.35,-17.31,;29.57,-15.98,;31.89,-17.31,;32.64,-15.97,;31.74,-14.71,;30.2,-14.71,;32.65,-13.46,;34.12,-13.94,;35.45,-13.17,;35.44,-11.63,;36.78,-10.86,;38.11,-11.63,;39.44,-10.86,;40.77,-11.64,;40.76,-13.17,;42.08,-13.95,;43.42,-13.2,;43.43,-11.66,;42.11,-10.87,;36.78,-13.94,;36.79,-15.49,;38.12,-16.26,;35.45,-16.26,;34.12,-15.49,;32.68,-18.62,;34.22,-18.59,;31.93,-19.96,)| | ||
| Structure | 
| ||