Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 1

Ligand

BDBM50342727

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_744206 (CHEMBL1771963)

IC50

207±n/a nM

Citation

Griffith, DA; Hargrove, DM; Maurer, TS; Blum, CA; De Lombaert, S; Inthavongsay, JK; Klade, LE; Mack, CM; Rose, CR; Sanders, MJ; Carpino, PA Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists. Bioorg Med Chem Lett21:2641-5 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuropeptide Y receptor type 1

Name:

Neuropeptide Y receptor type 1

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

44399.07

Organism:

Homo sapiens (Human)

Description:

NPY-Y1 NPY1R HUMAN::P25929

Residue:

384

Sequence:

MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLA
LIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQ
CVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMT
DEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKR
RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL
LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVS
KTSLKQASPVAFKKINNNDDNEKI

BDBM50342727

n/a

Name

BDBM50342727

Synonyms:

CHEMBL1771261 | N1-(3-(2,6-dichloro-4-propoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl)-N2-(tetrahydro-2H-pyran-4-yl)ethane-1,2-diamine

Type

Small organic molecule

Emp. Form.

C24H31Cl2N5O2

Mol. Mass.

492.441

SMILES

CCCOc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 |(5.54,-21.28,;7.08,-21.27,;7.87,-22.59,;9.41,-22.57,;10.16,-21.23,;9.38,-19.9,;10.14,-18.56,;9.36,-17.24,;11.67,-18.56,;12.43,-17.22,;11.52,-15.96,;9.98,-15.96,;12.43,-14.71,;13.9,-15.19,;15.23,-14.43,;15.23,-12.89,;16.56,-12.11,;17.9,-12.88,;19.23,-12.11,;20.56,-12.89,;20.54,-14.43,;21.86,-15.21,;23.2,-14.45,;23.22,-12.91,;21.89,-12.12,;16.57,-15.19,;16.57,-16.74,;17.91,-17.51,;15.24,-17.51,;13.9,-16.74,;12.46,-19.87,;14,-19.85,;11.71,-21.21,)|

Structure