Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50342734 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_744265 (CHEMBL1772072) | ||
| Ki | 4474±n/a nM | ||
| Citation |  Griffith, DA; Hargrove, DM; Maurer, TS; Blum, CA; De Lombaert, S; Inthavongsay, JK; Klade, LE; Mack, CM; Rose, CR; Sanders, MJ; Carpino, PA Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists. Bioorg Med Chem Lett21:2641-5 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
| ||
| BDBM50342734 | |||
| n/a | |||
| Name | BDBM50342734 | ||
| Synonyms: | CHEMBL1771267 | N-(2-Aminoethyl)-N-ethyl-9-mesityl-2-methyl-9H-pyrimido[4, 5-b]indol-4-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H29N5 | ||
| Mol. Mass. | 387.5206 | ||
| SMILES | CCN(CCN)c1nc(C)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3c12 |(1.53,-.87,;2.87,-.1,;4.2,-.86,;5.53,-.09,;6.87,-.86,;8.2,-.08,;4.2,-2.4,;5.54,-3.17,;5.54,-4.72,;6.88,-5.48,;4.21,-5.49,;2.87,-4.72,;1.4,-5.19,;.64,-6.53,;-.89,-6.54,;-1.67,-5.21,;-1.65,-7.88,;-.86,-9.21,;-1.62,-10.55,;.68,-9.19,;1.43,-7.85,;2.97,-7.82,;.49,-3.94,;-1.04,-3.78,;-1.67,-2.38,;-.76,-1.12,;.78,-1.28,;1.4,-2.69,;2.88,-3.17,)| | ||
| Structure | 
| ||