| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein-S-isoprenylcysteine O-methyltransferase |
|---|
| Ligand | BDBM50342743 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_744272 (CHEMBL1772079) |
|---|
| IC50 | 18400±n/a nM |
|---|
| Citation |  Majmudar, JD; Hahne, K; Hrycyna, CA; Gibbs, RA Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors. Bioorg Med Chem Lett21:2616-20 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein-S-isoprenylcysteine O-methyltransferase |
|---|
| Name: | Protein-S-isoprenylcysteine O-methyltransferase |
|---|
| Synonyms: | ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 31943.26 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_956034 |
|---|
| Residue: | 284 |
|---|
| Sequence: | MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
|
|
|
|---|
| BDBM50342743 |
|---|
| n/a |
|---|
| Name | BDBM50342743 |
|---|
| Synonyms: | (R)-2-(2-phenoxyphenylsulfonamido)-3-(3,7,11-trimethyldodeca-2,6,10-trienylthio)propanoic acid | CHEMBL1771313 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H39NO5S2 |
|---|
| Mol. Mass. | 557.764 |
|---|
| SMILES | [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#16]-[#6]-[#6@H](-[#7]S(=O)(=O)c1ccccc1-[#8]-c1ccccc1)-[#6](-[#8])=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
