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TargetIsoprenylcysteine carboxyl methyltransferase
LigandBDBM50342745
Substrate/Competitorn/a
Meas. Tech.ChEMBL_744272
IC50 11600±n/a nM
Citation Majmudar JDHahne KHrycyna CAGibbs RA Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors. Bioorg Med Chem Lett 21:2616-20 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Isoprenylcysteine carboxyl methyltransferase
Name:Isoprenylcysteine carboxyl methyltransferase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:31943.26
Organism:Homo sapiens (Human)
Description:ChEMBL_956034
Residue:284
Sequence:
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
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  Blast E-value cutoff:
BDBM50342745
n/a
NameBDBM50342745
Synonyms:(R)-2-(5-(dimethylamino)naphthalene-1-sulfonamido)-3-(3,7,11-trimethyldodeca-2,6,10-trienylthio)propanoic acid | CHEMBL1771299
TypeSmall organic molecule
Emp. Form.C30H42N2O4S2
Mol. Mass.558.795
SMILES[#6]-[#7](-[#6])-c1cccc2c(cccc12)S(=O)(=O)[#7]-[#6@@H](-[#6]-[#16]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])-[#6](-[#8])=O |r|
Structure
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