Reaction Details |
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Target | Histone deacetylase 2 |
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Ligand | BDBM50342753 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_744275 (CHEMBL1772082) |
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IC50 | 5000±n/a nM |
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Citation | Tang, W; Luo, T; Greenberg, EF; Bradner, JE; Schreiber, SL Discovery of histone deacetylase 8 selective inhibitors. Bioorg Med Chem Lett21:2601-5 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 2 |
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Name: | Histone deacetylase 2 |
Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 55356.54 |
Organism: | Homo sapiens (Human) |
Description: | Q92769 |
Residue: | 488 |
Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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BDBM50342753 |
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n/a |
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Name | BDBM50342753 |
Synonyms: | 3-(2-(3-(((S)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-4-yl)methyl)benzylidene)hydrazinecarbonyl)-N-hydroxybenzamide | CHEMBL1771487 |
Type | Small organic molecule |
Emp. Form. | C32H32N4O6 |
Mol. Mass. | 568.6197 |
SMILES | ONC(=O)c1cccc(c1)C(=O)NN=Cc1cccc(CN2C[C@@H](OC(=O)CC\C=C\CCC2=O)c2ccccc2)c1 |r,w:14.15,t:30| |
Structure |
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