| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50342750 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_744276 (CHEMBL1772083) |
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| IC50 | 290±n/a nM |
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| Citation |  Tang, W; Luo, T; Greenberg, EF; Bradner, JE; Schreiber, SL Discovery of histone deacetylase 8 selective inhibitors. Bioorg Med Chem Lett21:2601-5 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50342750 |
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| n/a |
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| Name | BDBM50342750 |
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| Synonyms: | CHEMBL1771484 | N,8-dihydroxy-8-(2-(4-(prop-2-ynyloxy)benzylidene)hydrazinyl)octanamide |
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| Type | Small organic molecule |
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| Emp. Form. | C18H23N3O4 |
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| Mol. Mass. | 345.3929 |
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| SMILES | ONC(=O)CCCCCCC(=O)NN=Cc1ccc(OCC#C)cc1 |w:14.14| |
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| Structure | 
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