| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 5 member 4 |
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| Ligand | BDBM50342889 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_745217 (CHEMBL1772493) |
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| IC50 | 1.07±n/a nM |
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| Citation |  Mascitti, V; Maurer, TS; Robinson, RP; Bian, J; Boustany-Kari, CM; Brandt, T; Collman, BM; Kalgutkar, AS; Klenotic, MK; Leininger, MT; Lowe, A; Maguire, RJ; Masterson, VM; Miao, Z; Mukaiyama, E; Patel, JD; Pettersen, JC; Préville, C; Samas, B; She, L; Sobol, Z; Steppan, CM; Stevens, BD; Thuma, BA; Tugnait, M; Zeng, D; Zhu, T Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors. J Med Chem54:2952-60 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 5 member 4 |
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| Name: | Solute carrier family 5 member 4 |
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| Synonyms: | Low affinity sodium-glucose cotransporter | Na(+)/glucose cotransporter 3 | SAAT1 | SC5A4_HUMAN | SGLT3 | SLC5A4 | Sodium/glucose cotransporter 3 | Solute carrier family 5 member 4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 72452.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_764617 |
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| Residue: | 659 |
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| Sequence: | MASTVSPSTIAETPEPPPLSDHIRNAADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFL
AGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIY
IKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLA
IFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNAT
PSVVEGDNLTISASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQR
CLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVG
CTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEK
ELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRV
NEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLV
TLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIDAEEKSQEETDDGVEEDYPEKSRGCLK
KAYDLFCGLQKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA
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| BDBM50342889 |
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| n/a |
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| Name | BDBM50342889 |
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| Synonyms: | (1S,2S,3S,4R,5S)-1-(Hydroxymethyl)-5-[3-(4-methoxybenzyl)-4-methylphenyl]-6,8-dioxa-bicyclo[3.2.1]octane-2,3,4-triol | CHEMBL1770244 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26O7 |
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| Mol. Mass. | 402.4376 |
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| SMILES | COc1ccc(Cc2cc(ccc2C)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1 |r| |
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| Structure | 
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