| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK2 |
|---|
| Ligand | BDBM50342918 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_744228 (CHEMBL1772035) |
|---|
| IC50 | 2725±n/a nM |
|---|
| Citation |  Rosenthal, AS; Tanega, C; Shen, M; Mott, BT; Bougie, JM; Nguyen, DT; Misteli, T; Auld, DS; Maloney, DJ; Thomas, CJ Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk). Bioorg Med Chem Lett21:3152-8 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity protein kinase CLK2 |
|---|
| Name: | Dual specificity protein kinase CLK2 |
|---|
| Synonyms: | 2.7.12.1 | CDC-like kinase 2 | CDC-like kinase 2 (CLK2) | CDC2-like kinase 2 (CLK2) | CLK2 | CLK2_HUMAN |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 60128.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49760 |
|---|
| Residue: | 499 |
|---|
| Sequence: | MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYD
DRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRR
RRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQC
VDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMC
ISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVN
SDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQ
PCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLD
WDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFA
RLRAEPPNKLWDSSRDISR
|
|
|
|---|
| BDBM50342918 |
|---|
| n/a |
|---|
| Name | BDBM50342918 |
|---|
| Synonyms: | 6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylfuran-3-yl)methyl)quinazolin-4-amine | CHEMBL1476499 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H17N3O3 |
|---|
| Mol. Mass. | 359.378 |
|---|
| SMILES | Cc1occc1CNc1ncnc2ccc(cc12)-c1ccc2OCOc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
