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TargetDual specificity protein kinase CLK4
LigandBDBM50342919
Substrate/Competitorn/a
Meas. Tech.ChEMBL_744201
IC50 37±n/a nM
Citation Rosenthal ASTanega CShen MMott BTBougie JMNguyen DTMisteli TAuld DSMaloney DJThomas CJ Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk). Bioorg Med Chem Lett 21:3152-8 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity protein kinase CLK4
Name:Dual specificity protein kinase CLK1/CLK4
Synonyms:CDC-like kinase 4 | CLK4
Type:Serine/threonine-protein kinase
Mol. Mass.:57522.53
Organism:Homo sapiens (Human)
Description:gi_10190706
Residue:481
Sequence:
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEAR
SLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRH
CSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG
MDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE
LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV
VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV
WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEH
SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK
K
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  Blast E-value cutoff:
BDBM50342919
n/a
NameBDBM50342919
Synonyms:6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((4-methylthiazol-2-yl)methyl)quinazolin-4-amine | CHEMBL1704879
TypeSmall organic molecule
Emp. Form.C21H18N4O2S
Mol. Mass.390.458
SMILESCN(Cc1nc(C)cs1)c1ncnc2ccc(cc12)-c1ccc2OCOc2c1
Structure
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