| Reaction Details |
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 | Report a problem with these data |
| Target | Disintegrin and metalloproteinase domain-containing protein 10 |
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| Ligand | BDBM50342945 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_744290 (CHEMBL1772147) |
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| Ki | 1350±n/a nM |
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| Citation |  Dai, C; Li, D; Popovici-Muller, J; Zhao, L; Girijavallabhan, VM; Rosner, KE; Lavey, BJ; Rizvi, R; Shankar, BB; Wong, MK; Guo, Z; Orth, P; Strickland, CO; Sun, J; Niu, X; Chen, S; Kozlowski, JA; Lundell, DJ; Piwinski, JJ; Shih, NY; Siddiqui, MA 2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors. Bioorg Med Chem Lett21:3172-6 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Disintegrin and metalloproteinase domain-containing protein 10 |
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| Name: | Disintegrin and metalloproteinase domain-containing protein 10 |
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| Synonyms: | ADA10_HUMAN | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) | KUZ | MADM |
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| Type: | Enzyme |
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| Mol. Mass.: | 84160.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14672 |
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| Residue: | 748 |
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| Sequence: | MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
KRRRPPQPIQQPQRQRPRESYQMGHMRR
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| BDBM50342945 |
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| n/a |
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| Name | BDBM50342945 |
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| Synonyms: | (2R,3R)-N-((R)-1-(4-(1H-pyrazol-1-yl)phenyl)ethyl)-4-((R)-2-(2-(cyclopropylamino)thiazol-4-yl)pyrrolidin-1-yl)-2,3-dihydroxy-4-oxobutanamide | CHEMBL1770649 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30N6O4S |
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| Mol. Mass. | 510.608 |
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| SMILES | C[C@@H](NC(=O)[C@H](O)[C@@H](O)C(=O)N1CCC[C@@H]1c1csc(NC2CC2)n1)c1ccc(cc1)-n1cccn1 |r| |
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| Structure | 
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