Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetP2Y purinoceptor 14
LigandBDBM50343111
Substrate/Competitorn/a
Meas. Tech.ChEMBL_745158 (CHEMBL1772337)
IC50 160±n/a nM
Citation Guay, DBeaulieu, CBelley, MCrane, SNDeLuca, JGareau, YHamel, MHenault, MHyjazie, HKargman, SChan, CCXu, LGordon, RLi, LMamane, YMorin, NMancini, JThérien, MTranmer, GTruong, VLWang, ZBlack, WC Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y14 receptor antagonists. Bioorg Med Chem Lett21:2832-5 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
P2Y purinoceptor 14
Name:P2Y purinoceptor 14
Synonyms:G-protein coupled receptor 105 | Gpr105 | P2Y14 | P2Y14_MOUSE | P2ry14 | UDP-glucose receptor
Type:PROTEIN
Mol. Mass.:38883.93
Organism:Mus musculus
Description:ChEMBL_745158
Residue:338
Sequence:
MNNSTTTDPPNQPCSWNTLITKQIIPVLYGMVFITGLLLNGISGWIFFYVPSSKSFIIYL
KNIVVADFLMGLTFPFKVLGDSGLGPWQVNVFVCRVSAVIFYVNMYVSIVFFGLISFDRY
YKIVKPLLTSIVQSVNYSKLLSVLVWMLMLLLAVPNIILTNQGVKEVTKIQCMELKNELG
RKWHKASNYIFVSIFWVVFLLLIVFYTAITRKIFKSHLKSRKNSTSVKRKSSRNIFSIVL
VFVVCFVPYHIARIPYTKSQTEGHYSCRTKETLLYAKEFTLLLSAANVCLDPIIYFFLCQ
PFREVLNKKLHMSLKVQNDLEVSKTKRENAIHESTDTL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50343111
n/a
NameBDBM50343111
Synonyms:CHEMBL1771246 | N-(3-chloro-5-ethylphenyl)-2-(pyridin-3-yl)-4-o-tolyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
TypeSmall organic molecule
Emp. Form.C28H26ClN5O
Mol. Mass.483.992
SMILESCCc1cc(Cl)cc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cccnc2)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: