| Reaction Details |
|---|
 | Report a problem with these data |
| Target | RAC-alpha serine/threonine-protein kinase |
|---|
| Ligand | BDBM50343198 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_745561 (CHEMBL1775878) |
|---|
| IC50 | 739±n/a nM |
|---|
| Citation |  D'Angelo, ND; Kim, TS; Andrews, K; Booker, SK; Caenepeel, S; Chen, K; D'Amico, D; Freeman, D; Jiang, J; Liu, L; McCarter, JD; San Miguel, T; Mullady, EL; Schrag, M; Subramanian, R; Tang, J; Wahl, RC; Wang, L; Whittington, DA; Wu, T; Xi, N; Xu, Y; Yakowec, P; Yang, K; Zalameda, LP; Zhang, N; Hughes, P; Norman, MH Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors. J Med Chem54:1789-811 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| RAC-alpha serine/threonine-protein kinase |
|---|
| Name: | RAC-alpha serine/threonine-protein kinase |
|---|
| Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55681.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P31749 |
|---|
| Residue: | 480 |
|---|
| Sequence: | MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
|
|
|
|---|
| BDBM50343198 |
|---|
| n/a |
|---|
| Name | BDBM50343198 |
|---|
| Synonyms: | CHEMBL1773600 | N-(6-(6-(4-Methoxyphenylsulfonamido)pyrazin-2-yl)benzo-[d]thiazol-2-yl)acetamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H17N5O4S2 |
|---|
| Mol. Mass. | 455.51 |
|---|
| SMILES | COc1ccc(cc1)S(=O)(=O)Nc1cncc(n1)-c1ccc2nc(NC(C)=O)sc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
