Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50343252 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_745569 (CHEMBL1775886) |
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Ki | 2260±n/a nM |
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Citation | Lozama, A; Cunningham, CW; Caspers, MJ; Douglas, JT; Dersch, CM; Rothman, RB; Prisinzano, TE Opioid receptor probes derived from cycloaddition of the hallucinogen natural product salvinorin A. J Nat Prod74:718-26 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50343252 |
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n/a |
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Name | BDBM50343252 |
Synonyms: | CHEMBL1773747 | Diethyl 5-((2S,4aR,6aR,7R,9S,10aS,10bR)-9-acetoxy-7-(methoxycarbonyl)-6a,10b-dimethyl-4,10-dioxododecahydro-1H-benzo[f]isochromen-2-yl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate |
Type | Small organic molecule |
Emp. Form. | C31H38O12 |
Mol. Mass. | 602.6262 |
SMILES | CCOC(=O)C1=C(C2OC1C=C2[C@@H]1C[C@@]2(C)[C@@H](CC[C@@]3(C)[C@@H](C[C@H](OC(C)=O)C(=O)[C@H]23)C(=O)OC)C(=O)O1)C(=O)OCC |r,c:11,t:5,TLB:3:5:11.10:8,12:11:8:5.6,THB:38:6:11.10:8| |
Structure |
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