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TargetRibonucleoside-diphosphate reductase large subunit/subunit M2 B
LigandBDBM50214817
Substrate/Competitorn/a
Meas. Tech.ChEMBL_745616 (CHEMBL1775986)
IC50 244000±n/a nM
Citation Cappellacci, LPetrelli, RFranchetti, PVita, PKusumanchi, PKumar, MJayaram, HNZhou, BYen, YGrifantini, M Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents. Eur J Med Chem46:1499-504 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ribonucleoside-diphosphate reductase large subunit/subunit M2 B
Name:Ribonucleoside-diphosphate reductase large subunit/subunit M2 B
Synonyms:Ribonucleoside-diphosphate reductase M1 chain/Ribonucleotide reductase | Ribonucleotide reductase
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 745616
Components:This complex has 2 components.
Component 1
Name:Ribonucleoside-diphosphate reductase large subunit
Synonyms:RIR1_HUMAN | RR1 | RRM1 | Ribonucleoside-diphosphate reductase M1 chain | Ribonucleoside-diphosphate reductase subunit M1 | Ribonucleotide reductase large subunit
Type:PROTEIN
Mol. Mass.:90074.67
Organism:Homo sapiens (Human)
Description:ChEMBL_90946
Residue:792
Sequence:
MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLA
AETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKST
LDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHK
EDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL
ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY
LEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLD
EVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL
GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKI
IDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL
EASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIA
PMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQII
ACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKL
TSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCS
LENRDECLMCGS
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Component 2
Name:Ribonucleoside-diphosphate reductase subunit M2 B
Synonyms:P53R2 | RIR2B_HUMAN | RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B | Ribonucleotide reductase | TP53-inducible ribonucleotide reductase M2 B | p53-inducible ribonucleotide reductase small subunit 2-like protein
Type:PROTEIN
Mol. Mass.:40721.91
Organism:Homo sapiens (Human)
Description:EBI_318
Residue:351
Sequence:
MGDPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQ
ASFWTAEEVDLSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEA
RCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRK
STFGERVVAFAAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQ
YLVNKPSEERVREIIVDAVKIEQEFLTEALPVGLIGMNCILMKQYIEFVADRLLVELGFS
KVFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF
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BDBM50214817
n/a
NameBDBM50214817
Synonyms:CHEMBL236757 | N6-aminoadenosine
TypeSmall organic molecule
Emp. Form.C10H14N6O4
Mol. Mass.282.256
SMILESNNc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Structure
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