Reaction Details |
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Target | Ribonucleoside-diphosphate reductase large subunit/subunit M2 B |
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Ligand | BDBM50214817 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_745616 (CHEMBL1775986) |
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IC50 | 244000±n/a nM |
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Citation | Cappellacci, L; Petrelli, R; Franchetti, P; Vita, P; Kusumanchi, P; Kumar, M; Jayaram, HN; Zhou, B; Yen, Y; Grifantini, M Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents. Eur J Med Chem46:1499-504 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ribonucleoside-diphosphate reductase large subunit/subunit M2 B |
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Name: | Ribonucleoside-diphosphate reductase large subunit/subunit M2 B |
Synonyms: | Ribonucleoside-diphosphate reductase M1 chain/Ribonucleotide reductase | Ribonucleotide reductase |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 745616 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Ribonucleoside-diphosphate reductase large subunit |
Synonyms: | RIR1_HUMAN | RR1 | RRM1 | Ribonucleoside-diphosphate reductase M1 chain | Ribonucleoside-diphosphate reductase subunit M1 | Ribonucleotide reductase large subunit |
Type: | PROTEIN |
Mol. Mass.: | 90074.67 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_90946 |
Residue: | 792 |
Sequence: | MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLA
AETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKST
LDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHK
EDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL
ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY
LEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLD
EVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL
GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKI
IDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL
EASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIA
PMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQII
ACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKL
TSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCS
LENRDECLMCGS
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Component 2 |
Name: | Ribonucleoside-diphosphate reductase subunit M2 B |
Synonyms: | P53R2 | RIR2B_HUMAN | RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B | Ribonucleotide reductase | TP53-inducible ribonucleotide reductase M2 B | p53-inducible ribonucleotide reductase small subunit 2-like protein |
Type: | PROTEIN |
Mol. Mass.: | 40721.91 |
Organism: | Homo sapiens (Human) |
Description: | EBI_318 |
Residue: | 351 |
Sequence: | MGDPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQ
ASFWTAEEVDLSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEA
RCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRK
STFGERVVAFAAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQ
YLVNKPSEERVREIIVDAVKIEQEFLTEALPVGLIGMNCILMKQYIEFVADRLLVELGFS
KVFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF
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BDBM50214817 |
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n/a |
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Name | BDBM50214817 |
Synonyms: | CHEMBL236757 | N6-aminoadenosine |
Type | Small organic molecule |
Emp. Form. | C10H14N6O4 |
Mol. Mass. | 282.256 |
SMILES | NNc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |
Structure |
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