| Reaction Details |
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 | Report a problem with these data |
| Target | D(2) dopamine receptor |
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| Ligand | BDBM50343325 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_745694 (CHEMBL1776064) |
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| Ki | >5260±n/a nM |
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| Citation |  Zhang, L; Brodney, MA; Candler, J; Doran, AC; Duplantier, AJ; Efremov, IV; Evrard, E; Kraus, K; Ganong, AH; Haas, JA; Hanks, AN; Jenza, K; Lazzaro, JT; Maklad, N; McCarthy, SA; Qian, W; Rogers, BN; Rottas, MD; Schmidt, CJ; Siuciak, JA; Tingley, FD; Zhang, AQ 1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis. J Med Chem54:1724-39 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(2) dopamine receptor |
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| Name: | D(2) dopamine receptor |
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| Synonyms: | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 50931.60 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P61169 |
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| Residue: | 444 |
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| Sequence: | MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
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| BDBM50343325 |
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| n/a |
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| Name | BDBM50343325 |
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| Synonyms: | CHEMBL1774233 | cis-2-(((3R,4R)-4-(2-fluoro-4-(trifluoromethyl)phenyl)-3-methylpiperidin-1-yl)methyl)-1-methyl-1H-imidazo[4,5-b]pyridine |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22F4N4 |
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| Mol. Mass. | 406.4198 |
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| SMILES | C[C@H]1CN(Cc2nc3ncccc3n2C)CC[C@H]1c1ccc(cc1F)C(F)(F)F |r| |
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| Structure | 
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