| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cholecystokinin receptor type A |
|---|
| Ligand | BDBM50343709 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_746073 (CHEMBL1775460) |
|---|
| IC50 | 6.7±n/a nM |
|---|
| Citation |  Wang, L; Hubert, JA; Lee, SJ; Pan, J; Qian, S; Reitman, ML; Strack, AM; Weingarth, DT; MacNeil, DJ; Weber, AE; Edmondson, SD Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists. Bioorg Med Chem Lett21:2911-5 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cholecystokinin receptor type A |
|---|
| Name: | Cholecystokinin receptor type A |
|---|
| Synonyms: | CCK-A receptor | CCK-AR | CCK1-R | CCKAR | CCKAR_HUMAN | CCKRA | Cholecystokinin receptor | Cholecystokinin receptor type A | Cholecystokinin-1 Receptor |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 47859.34 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Stable expression of human CCK-1 receptors in HEK 293 cells. |
|---|
| Residue: | 428 |
|---|
| Sequence: | MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNT
LVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYF
MGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYS
NLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGI
KFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNS
SAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSY
TSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSH
MSASVPPQ
|
|
|
|---|
| BDBM50343709 |
|---|
| n/a |
|---|
| Name | BDBM50343709 |
|---|
| Synonyms: | (4-(4-fluorophenyl)-5-(4-methoxyphenyl)pyrimidin-2-yl)(4-(quinolin-3-yl)piperazin-1-yl)methanone | CHEMBL1773896 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H26FN5O2 |
|---|
| Mol. Mass. | 519.5688 |
|---|
| SMILES | COc1ccc(cc1)-c1cnc(nc1-c1ccc(F)cc1)C(=O)N1CCN(CC1)c1cnc2ccccc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
