| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily E member 1 |
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| Ligand | BDBM50343722 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_746072 (CHEMBL1775459) |
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| IC50 | >10000±n/a nM |
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| Citation |  Wang, L; Hubert, JA; Lee, SJ; Pan, J; Qian, S; Reitman, ML; Strack, AM; Weingarth, DT; MacNeil, DJ; Weber, AE; Edmondson, SD Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists. Bioorg Med Chem Lett21:2911-5 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily E member 1 |
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| Name: | Potassium voltage-gated channel subfamily E member 1 |
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| Synonyms: | Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNE1 | KCNE1_HUMAN | KCNQ1(Kv7.1)/KCNE1(MinK) | Minimal potassium channel | Voltage-gated potassium channel beta subunit Mink | Voltage-gated potassium channel, IKs |
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| Type: | PROTEIN |
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| Mol. Mass.: | 14676.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1456351 |
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| Residue: | 129 |
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| Sequence: | MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLG
IMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNT
HLPETKPSP
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| BDBM50343722 |
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| n/a |
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| Name | BDBM50343722 |
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| Synonyms: | 3-(4-(5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-(2-fluoro-4-methylphenyl)pyrimidine-2-carbonyl)piperazin-1-yl)-1-naphthoic acid | CHEMBL1773877 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H29FN4O5 |
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| Mol. Mass. | 604.627 |
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| SMILES | Cc1ccc(c(F)c1)-c1nc(ncc1-c1ccc2OCCOc2c1)C(=O)N1CCN(CC1)c1cc(C(O)=O)c2ccccc2c1 |
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| Structure | 
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