| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscle, skeletal receptor tyrosine-protein kinase |
|---|
| Ligand | BDBM50343726 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_746726 (CHEMBL1776851) |
|---|
| IC50 | 224±n/a nM |
|---|
| Citation |  Wang, T; Ioannidis, S; Almeida, L; Block, MH; Davies, AM; Lamb, ML; Scott, DA; Su, M; Zhang, HJ; Alimzhanov, M; Bebernitz, G; Bell, K; Zinda, M In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors. Bioorg Med Chem Lett21:2958-61 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Muscle, skeletal receptor tyrosine-protein kinase |
|---|
| Name: | Muscle, skeletal receptor tyrosine-protein kinase |
|---|
| Synonyms: | MUSK | MUSK_HUMAN | Muscle, skeletal receptor tyrosine protein kinase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 97062.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1474077 |
|---|
| Residue: | 869 |
|---|
| Sequence: | MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEIS
WTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMK
PKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNV
QKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPV
PTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAAT
ISIAEWSKPQKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELK
VVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRG
LYRSEMHLLSVPECSKLPSMHWDPTACARLPHLDYNKENLKTFPPMTSSKPSVDIPNLPS
SSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLP
SELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPY
EPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAY
GDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERK
FVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYT
TESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWS
KLPADRPSFTSIHRILERMCERAEGTVSV
|
|
|
|---|
| BDBM50343726 |
|---|
| n/a |
|---|
| Name | BDBM50343726 |
|---|
| Synonyms: | (S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile | CHEMBL1774056 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H15F2N7 |
|---|
| Mol. Mass. | 355.3447 |
|---|
| SMILES | C[C@H](Nc1nc(Nc2cc(C)n[nH]2)c(F)cc1C#N)c1ccc(F)cn1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
