Reaction Details |
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Target | P2Y purinoceptor 14 |
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Ligand | BDBM50343888 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_747401 (CHEMBL1776795) |
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IC50 | 8±n/a nM |
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Citation | Gauthier, JY; Belley, M; Deschênes, D; Fournier, JF; Gagné, S; Gareau, Y; Hamel, M; Hénault, M; Hyjazie, H; Kargman, S; Lavallée, G; Levesque, JF; Li, L; Mamane, Y; Mancini, J; Morin, N; Mulrooney, E; Robichaud, J; Thérien, M; Tranmer, G; Wang, Z; Wu, J; Black, WC The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14. Bioorg Med Chem Lett21:2836-9 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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P2Y purinoceptor 14 |
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Name: | P2Y purinoceptor 14 |
Synonyms: | G-protein coupled receptor 105 | Gpr105 | P2Y14 | P2Y14_MOUSE | P2ry14 | UDP-glucose receptor |
Type: | PROTEIN |
Mol. Mass.: | 38883.93 |
Organism: | Mus musculus |
Description: | ChEMBL_745158 |
Residue: | 338 |
Sequence: | MNNSTTTDPPNQPCSWNTLITKQIIPVLYGMVFITGLLLNGISGWIFFYVPSSKSFIIYL
KNIVVADFLMGLTFPFKVLGDSGLGPWQVNVFVCRVSAVIFYVNMYVSIVFFGLISFDRY
YKIVKPLLTSIVQSVNYSKLLSVLVWMLMLLLAVPNIILTNQGVKEVTKIQCMELKNELG
RKWHKASNYIFVSIFWVVFLLLIVFYTAITRKIFKSHLKSRKNSTSVKRKSSRNIFSIVL
VFVVCFVPYHIARIPYTKSQTEGHYSCRTKETLLYAKEFTLLLSAANVCLDPIIYFFLCQ
PFREVLNKKLHMSLKVQNDLEVSKTKRENAIHESTDTL
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BDBM50343888 |
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n/a |
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Name | BDBM50343888 |
Synonyms: | (R)-4-(4-(2,2-difluoro-1-hydroxyethyl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid | CHEMBL1774903 |
Type | Small organic molecule |
Emp. Form. | C26H17F5O3 |
Mol. Mass. | 472.4034 |
SMILES | O[C@@H](C(F)F)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O |r| |
Structure |
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