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TargetMannose-6-phosphate isomerase
LigandBDBM44457
Substrate/Competitorn/a
Meas. Tech.ChEMBL_747525 (CHEMBL1777059)
IC50 1900±n/a nM
Citation Dahl, RBravo, YSharma, VIchikawa, MDhanya, RPHedrick, MBrown, BRascon, JVicchiarelli, MMangravita-Novo, AYang, LStonich, DSu, YSmith, LHSergienko, EFreeze, HHCosford, ND Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia. J Med Chem54:3661-8 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mannose-6-phosphate isomerase
Name:Mannose-6-phosphate isomerase
Synonyms:MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:PROTEIN
Mol. Mass.:46651.35
Organism:Homo sapiens (Human)
Description:ChEMBL_1448919
Residue:423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAK
ILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEK
LHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLK
QTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQ
LHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTP
KFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYK
VLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRAC
CLL
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  Blast E-value cutoff:
BDBM44457
n/a
NameBDBM44457
Synonyms:(4Z)-4-[(2-methylsulfanylanilino)methylidene]-2-phenyl-1,3-oxazol-5-one | (4Z)-4-[[(2-methylsulfanylphenyl)amino]methylidene]-2-phenyl-1,3-oxazol-5-one | (4Z)-4-[[2-(methylthio)anilino]methylene]-2-phenyl-2-oxazolin-5-one | (4Z)-4-[[2-(methylthio)anilino]methylidene]-2-phenyl-5-oxazolone | MLS000108925 | SMR000104873 | cid_5310789
TypeSmall organic molecule
Emp. Form.C17H14N2O2S
Mol. Mass.310.37
SMILESCSc1ccccc1N=Cc1nc(oc1O)-c1ccccc1 |w:8.8|
Structure
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