Reaction Details |
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Target | Mannose-6-phosphate isomerase |
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Ligand | BDBM44457 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_747525 (CHEMBL1777059) |
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IC50 | 1900±n/a nM |
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Citation | Dahl, R; Bravo, Y; Sharma, V; Ichikawa, M; Dhanya, RP; Hedrick, M; Brown, B; Rascon, J; Vicchiarelli, M; Mangravita-Novo, A; Yang, L; Stonich, D; Su, Y; Smith, LH; Sergienko, E; Freeze, HH; Cosford, ND Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia. J Med Chem54:3661-8 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mannose-6-phosphate isomerase |
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Name: | Mannose-6-phosphate isomerase |
Synonyms: | MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1 |
Type: | PROTEIN |
Mol. Mass.: | 46651.35 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1448919 |
Residue: | 423 |
Sequence: | MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAK
ILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEK
LHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLK
QTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQ
LHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTP
KFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYK
VLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRAC
CLL
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BDBM44457 |
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n/a |
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Name | BDBM44457 |
Synonyms: | (4Z)-4-[(2-methylsulfanylanilino)methylidene]-2-phenyl-1,3-oxazol-5-one | (4Z)-4-[[(2-methylsulfanylphenyl)amino]methylidene]-2-phenyl-1,3-oxazol-5-one | (4Z)-4-[[2-(methylthio)anilino]methylene]-2-phenyl-2-oxazolin-5-one | (4Z)-4-[[2-(methylthio)anilino]methylidene]-2-phenyl-5-oxazolone | MLS000108925 | SMR000104873 | cid_5310789 |
Type | Small organic molecule |
Emp. Form. | C17H14N2O2S |
Mol. Mass. | 310.37 |
SMILES | CSc1ccccc1N=Cc1nc(oc1O)-c1ccccc1 |w:8.8| |
Structure |
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