Reaction Details |
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Target | Mannose-6-phosphate isomerase |
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Ligand | BDBM44443 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_747525 (CHEMBL1777059) |
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IC50 | 1300±n/a nM |
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Citation | Dahl, R; Bravo, Y; Sharma, V; Ichikawa, M; Dhanya, RP; Hedrick, M; Brown, B; Rascon, J; Vicchiarelli, M; Mangravita-Novo, A; Yang, L; Stonich, D; Su, Y; Smith, LH; Sergienko, E; Freeze, HH; Cosford, ND Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia. J Med Chem54:3661-8 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mannose-6-phosphate isomerase |
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Name: | Mannose-6-phosphate isomerase |
Synonyms: | MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1 |
Type: | PROTEIN |
Mol. Mass.: | 46651.35 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1448919 |
Residue: | 423 |
Sequence: | MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAK
ILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEK
LHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLK
QTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQ
LHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTP
KFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYK
VLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRAC
CLL
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BDBM44443 |
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n/a |
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Name | BDBM44443 |
Synonyms: | 2-[1,3-bis(oxidanylidene)isoindol-2-yl]-N-[3-cyano-4,5-bis(furan-2-yl)furan-2-yl]-4-methyl-pentanamide | MLS000054168 | N-[3-cyano-4,5-bis(2-furanyl)-2-furanyl]-2-(1,3-dioxo-2-isoindolyl)-4-methylpentanamide | N-[3-cyano-4,5-bis(2-furyl)-2-furyl]-4-methyl-2-phthalimido-valeramide | N-[3-cyano-4,5-bis(furan-2-yl)furan-2-yl]-2-(1,3-dioxoisoindol-2-yl)-4-methylpentanamide | SMR000062696 | cid_2998795 |
Type | Small organic molecule |
Emp. Form. | C27H21N3O6 |
Mol. Mass. | 483.4721 |
SMILES | CC(C)CC(N1C(=O)c2ccccc2C1=O)C(=O)Nc1oc(-c2ccco2)c(-c2ccco2)c1C#N |
Structure |
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