Reaction Details |
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Target | Mannose-6-phosphate isomerase |
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Ligand | BDBM44445 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_747525 (CHEMBL1777059) |
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IC50 | 1900±n/a nM |
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Citation | Dahl, R; Bravo, Y; Sharma, V; Ichikawa, M; Dhanya, RP; Hedrick, M; Brown, B; Rascon, J; Vicchiarelli, M; Mangravita-Novo, A; Yang, L; Stonich, D; Su, Y; Smith, LH; Sergienko, E; Freeze, HH; Cosford, ND Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia. J Med Chem54:3661-8 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mannose-6-phosphate isomerase |
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Name: | Mannose-6-phosphate isomerase |
Synonyms: | MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1 |
Type: | PROTEIN |
Mol. Mass.: | 46651.35 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1448919 |
Residue: | 423 |
Sequence: | MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAK
ILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEK
LHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLK
QTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQ
LHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTP
KFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYK
VLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRAC
CLL
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BDBM44445 |
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n/a |
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Name | BDBM44445 |
Synonyms: | 3-(1,3-benzodioxol-5-ylmethyl)-7-(piperidin-1-ylcarbonyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one | 3-(1,3-benzodioxol-5-ylmethyl)-7-(piperidine-1-carbonyl)-2-sulfanylidene-1H-quinazolin-4-one | 3-(1,3-benzodioxol-5-ylmethyl)-7-[oxo(1-piperidinyl)methyl]-2-sulfanylidene-1H-quinazolin-4-one | 3-(1,3-benzodioxol-5-ylmethyl)-7-piperidin-1-ylcarbonyl-2-sulfanylidene-1H-quinazolin-4-one | 7-(piperidine-1-carbonyl)-3-piperonyl-2-thioxo-1H-quinazolin-4-one | MLS000095530 | SMR000031083 | cid_3237126 |
Type | Small organic molecule |
Emp. Form. | C22H21N3O4S |
Mol. Mass. | 423.485 |
SMILES | O=C(N1CCCCC1)c1ccc2c(c1)[nH]c(=S)n(Cc1ccc3OCOc3c1)c2=O |
Structure |
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