| Reaction Details |
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 | Report a problem with these data |
| Target | Melatonin receptor type 1B |
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| Ligand | BDBM50343991 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_748405 (CHEMBL1781569) |
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| Ki | 0.24±n/a nM |
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| Citation |  Mésangeau, C; Fraise, M; Delagrange, P; Caignard, DH; Boutin, JA; Berthelot, P; Yous, S Preparation and pharmacological evaluation of a novel series of 2-(phenylthio)benzo[b]thiophenes as selective MT2 receptor ligands. Eur J Med Chem46:1835-40 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melatonin receptor type 1B |
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| Name: | Melatonin receptor type 1B |
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| Synonyms: | MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 40203.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49286 |
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| Residue: | 362 |
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| Sequence: | MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRL
CLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFN
SCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQAD
AL
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| BDBM50343991 |
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| n/a |
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| Name | BDBM50343991 |
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| Synonyms: | CHEMBL1779810 | N-(2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethyl)but-3-enamide |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17F2NOS2 |
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| Mol. Mass. | 389.482 |
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| SMILES | Fc1ccc(Sc2sc3ccc(F)cc3c2CCNC(=O)CC=C)cc1 |
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| Structure | 
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