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TargetB1 bradykinin receptor
LigandBDBM50209744
Substrate/Competitorn/a
Meas. Tech.ChEMBL_748609 (CHEMBL1780462)
IC50 0.8±n/a nM
Citation Chen, JJNguyen, TD'Amico, DCQian, WHuman, JAya, TBiswas, KFotsch, CHan, NLiu, QNishimura, NPeterkin, TAYang, KZhu, JRiahi, BBHungate, RWAndersen, NGColyer, JTFaul, MMKamassah, AWang, JJona, JKumar, GJohnson, EAskew, BC 3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation. Bioorg Med Chem Lett21:3384-9 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
B1 bradykinin receptor
Name:B1 bradykinin receptor
Synonyms:B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:Enzyme
Mol. Mass.:40508.87
Organism:Homo sapiens (Human)
Description:P46663
Residue:353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50209744
n/a
NameBDBM50209744
Synonyms:(R)-3-(4-fluorophenyl)-N-((R)-7-(piperidin-1-ylmethyl)-3,4-dihydro-2H-chromen-4-yl)-3-(3-(trifluoromethyl)phenylsulfonamido)propanamide | (R)-3-(4-fluorophenyl)-N-((R)-7-(piperidin-1-ylmethyl)chroman-4-yl)-3-(3-(trifluoromethyl)phenylsulfonamido)-propanamide | CHEMBL227713
TypeSmall organic molecule
Emp. Form.C31H33F4N3O4S
Mol. Mass.619.67
SMILESFc1ccc(cc1)[C@@H](CC(=O)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc12)NS(=O)(=O)c1cccc(c1)C(F)(F)F |r|
Structure
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