| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50344128 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_747811 (CHEMBL1781010) |
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| IC50 | 2200±n/a nM |
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| Citation |  Soth, M; Abbot, S; Abubakari, A; Arora, N; Arzeno, H; Billedeau, R; Dewdney, N; Durkin, K; Frauchiger, S; Ghate, M; Goldstein, DM; Hill, RJ; Kuglstatter, A; Li, F; Loe, B; McCaleb, K; McIntosh, J; Papp, E; Park, J; Stahl, M; Sung, ML; Suttman, R; Swinney, DC; Weller, P; Wong, B; Zecic, H; Gabriel, T 3-Amino-pyrazolo[3,4-d]pyrimidines as p38a kinase inhibitors: design and development to a highly selective lead. Bioorg Med Chem Lett21:3452-6 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50344128 |
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| n/a |
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| Name | BDBM50344128 |
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| Synonyms: | CHEMBL1778185 | [6-(2,4-Difluoro-phenoxy)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-(1,1-dioxo-hexahydro-1lambda*6*-thiopyran-4-yl)-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15F2N5O3S |
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| Mol. Mass. | 395.384 |
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| SMILES | Fc1ccc(Oc2ncc3c(NC4CCS(=O)(=O)CC4)[nH]nc3n2)c(F)c1 |
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| Structure | 
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