Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetAtrial natriuretic factor
LigandBDBM50344187
Substrate/Competitorn/a
Meas. Tech.ChEMBL_748204
IC50 1.5±n/a nM
Citation Glossop MSBazin RJDack KNFox DNMacDonald GAMills MOwen DRPhillips CReeves KARinger TJStrang RSWatson CA Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors. Bioorg Med Chem Lett 21:3404-6 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Atrial natriuretic factor
Name:Atrial natriuretic factor
Synonyms:ANF | ANP | Atrial natriuretic peptide | CDD-ANF | CDP | Cardiodilatin-related peptide | Natriuretic peptides A | Prepronatriodilatin
Type:PROTEIN
Mol. Mass.:16708.32
Organism:Homo sapiens (Human)
Description:ChEMBL_748204
Residue:153
Sequence:
MSSFSTTTVSFLLLLAFQLLGQTRANPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPP
QVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRGPWDSSDRSALLKSKLRALLT
APRSLRRSSCFGGRMDRIGAQSGLGCNSFRYRR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50344187
n/a
NameBDBM50344187
Synonyms:(S)-2-((S)-1-((S)-2-(biphenyl-4-yl)-1-carboxyethylamino)-5-methyl-1-oxohexan-2-ylamino)-4-phenylbutanoic acid | CHEMBL1778526
TypeSmall organic molecule
Emp. Form.C32H38N2O5
Mol. Mass.530.6545
SMILESCC(C)CC[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(O)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: