Reaction Details |
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Target | Natriuretic peptides A |
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Ligand | BDBM50344187 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_748204 (CHEMBL1780285) |
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IC50 | 1.5±n/a nM |
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Citation | Glossop, MS; Bazin, RJ; Dack, KN; Fox, DN; MacDonald, GA; Mills, M; Owen, DR; Phillips, C; Reeves, KA; Ringer, TJ; Strang, RS; Watson, CA Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors. Bioorg Med Chem Lett21:3404-6 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Natriuretic peptides A |
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Name: | Natriuretic peptides A |
Synonyms: | ANF | ANF_HUMAN | ANP | Atrial natriuretic factor | Atrial natriuretic peptide | CDD-ANF | CDP | Cardiodilatin-related peptide | NPPA | Natriuretic peptides A | PND | Prepronatriodilatin |
Type: | PROTEIN |
Mol. Mass.: | 16393.93 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_748204 |
Residue: | 151 |
Sequence: | MSSFSTTTVSFLLLLAFQLLGQTRANPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPP
QVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRGPWDSSDRSALLKSKLRALLT
APRSLRRSSCFGGRMDRIGAQSGLGCNSFRY
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BDBM50344187 |
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n/a |
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Name | BDBM50344187 |
Synonyms: | (S)-2-((S)-1-((S)-2-(biphenyl-4-yl)-1-carboxyethylamino)-5-methyl-1-oxohexan-2-ylamino)-4-phenylbutanoic acid | CHEMBL1778526 |
Type | Small organic molecule |
Emp. Form. | C32H38N2O5 |
Mol. Mass. | 530.6545 |
SMILES | CC(C)CC[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(O)=O |r| |
Structure |
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