Reaction Details |
| Report a problem with these data |
Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
---|
Ligand | BDBM50344328 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_748499 (CHEMBL1780352) |
---|
IC50 | 2610±n/a nM |
---|
Citation | Allcock, RW; Blakli, H; Jiang, Z; Johnston, KA; Morgan, KM; Rosair, GM; Iwase, K; Kohno, Y; Adams, DR Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast. Bioorg Med Chem Lett21:3307-12 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
---|
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) |
Type: | Protein |
Mol. Mass.: | 83318.87 |
Organism: | Homo sapiens (Human) |
Description: | Q07343 |
Residue: | 736 |
Sequence: | MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT
|
|
|
BDBM50344328 |
---|
n/a |
---|
Name | BDBM50344328 |
Synonyms: | 6-(2-isopropyl-7-methoxypyrazolo[1,5-a]pyridin-4-yl)-4,5-dihydropyridazin-3(2H)-one | CHEMBL1779446 |
Type | Small organic molecule |
Emp. Form. | C15H18N4O2 |
Mol. Mass. | 286.329 |
SMILES | COc1ccc(C2=NNC(=O)CC2)c2cc(nn12)C(C)C |t:6| |
Structure |
|