Ki Summary

Reaction Details

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Target

Sigma non-opioid intracellular receptor 1

Ligand

BDBM50344428

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_748646 (CHEMBL1780499)

>1000±n/a nM

Citation

Rack, E; Fröhlich, R; Schepmann, D; Wünsch, B Design, synthesis and pharmacological evaluation of spirocyclics(1) receptor ligands with exocyclic amino moiety (increased distance 1). Bioorg Med Chem19:3141-51 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sigma non-opioid intracellular receptor 1

Name:

Sigma non-opioid intracellular receptor 1

Synonyms:

Type:

Protein

Mol. Mass.:

25307.17

Organism:

Cavia porcellus (Guinea pig)

Description:

Q60492

Residue:

223

Sequence:

MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP

BDBM50344428

n/a

Name

BDBM50344428

Synonyms:

CHEMBL1780003 | cis-N,N-Dibenzyl-3-methoxy-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

Type

Small organic molecule

Emp. Form.

C29H33NO2

Mol. Mass.

427.5778

SMILES

COC1Cc2ccccc2[C@]2(CC[C@@H](CC2)N(Cc2ccccc2)Cc2ccccc2)O1 |r,wU:13.17,10.34,(2.28,-30.3,;.94,-31.06,;.94,-32.6,;2.27,-33.38,;2.26,-34.91,;3.58,-35.67,;3.58,-37.19,;2.25,-37.96,;.93,-37.19,;.93,-35.67,;-.4,-34.9,;-1.66,-35.32,;-3.3,-34.69,;-4.06,-36.05,;-2.88,-35.63,;-1.16,-36.24,;-5.4,-35.28,;-5.4,-33.74,;-4.07,-32.96,;-2.74,-33.74,;-1.41,-32.97,;-1.41,-31.42,;-2.75,-30.66,;-4.08,-31.43,;-6.74,-36.05,;-8.07,-35.28,;-8.08,-33.74,;-9.41,-32.97,;-10.75,-33.75,;-10.74,-35.29,;-9.41,-36.05,;-.4,-33.37,)|

Structure