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TargetSigma non-opioid intracellular receptor 1
LigandBDBM50344432
Substrate/Competitorn/a
Meas. Tech.ChEMBL_748646
Ki 174±n/a nM
Citation Rack EFröhlich RSchepmann DWünsch B Design, synthesis and pharmacological evaluation of spirocyclics(1) receptor ligands with exocyclic amino moiety (increased distance 1). Bioorg Med Chem 19:3141-51 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sigma non-opioid intracellular receptor 1
Name:Sigma-1 receptor
Synonyms:OPRS1 | SIGMAR1 | Sigma 1-type opioid receptor | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:Protein
Mol. Mass.:25307.17
Organism:Cavia porcellus (Guinea pig)
Description:Q60492
Residue:223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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BDBM50344432
n/a
NameBDBM50344432
Synonyms:CHEMBL1779996 | cis-N-(p-Methoxybenzyl)-3-methoxy-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine
TypeSmall organic molecule
Emp. Form.C23H29NO3
Mol. Mass.367.4813
SMILESCOC1Cc2ccccc2[C@]2(CC[C@@H](CC2)NCc2ccc(OC)cc2)O1 |r,wU:13.17,10.28,(14.88,-7.34,;13.54,-8.1,;13.54,-9.64,;14.87,-10.42,;14.86,-11.96,;16.17,-12.71,;16.17,-14.23,;14.85,-15.01,;13.53,-14.23,;13.54,-12.71,;12.2,-11.95,;10.93,-12.36,;9.3,-11.74,;8.53,-13.09,;9.72,-12.67,;11.43,-13.29,;7.2,-12.33,;7.2,-10.78,;5.86,-10.01,;5.86,-8.47,;4.53,-7.7,;3.19,-8.47,;1.85,-7.7,;.52,-8.48,;3.2,-10.02,;4.53,-10.79,;12.2,-10.41,)|
Structure
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