Ki Summary

Reaction Details

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Target

Sigma non-opioid intracellular receptor 1

Ligand

BDBM50344434

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_748646 (CHEMBL1780499)

>1000±n/a nM

Citation

Rack, E; Fröhlich, R; Schepmann, D; Wünsch, B Design, synthesis and pharmacological evaluation of spirocyclics(1) receptor ligands with exocyclic amino moiety (increased distance 1). Bioorg Med Chem19:3141-51 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sigma non-opioid intracellular receptor 1

Name:

Sigma non-opioid intracellular receptor 1

Synonyms:

Type:

Protein

Mol. Mass.:

25307.17

Organism:

Cavia porcellus (Guinea pig)

Description:

Q60492

Residue:

223

Sequence:

MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP

BDBM50344434

n/a

Name

BDBM50344434

Synonyms:

CHEMBL1779998 | cis-3-Methoxy-N,N-dimethyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

Type

Small organic molecule

Emp. Form.

C17H25NO2

Mol. Mass.

275.3859

SMILES

COC1Cc2ccccc2[C@]2(CC[C@@H](CC2)N(C)C)O1 |r,wU:10.20,13.17,(39.08,-6.58,;37.74,-7.35,;37.74,-8.9,;39.07,-9.67,;39.07,-11.22,;40.38,-11.98,;40.39,-13.5,;39.05,-14.27,;37.73,-13.5,;37.73,-11.97,;36.4,-11.21,;35.13,-11.62,;33.48,-11,;32.72,-12.36,;33.91,-11.93,;35.63,-12.55,;31.38,-11.59,;31.38,-10.04,;30.04,-12.36,;36.39,-9.67,)|

Structure